Abstract

Depression is common mental disorder which affects more than 300 million people worldwide. Treatment of depression’s methods have low positive effect and high side effect on patients. Therefore, new treatment methods have being researched. Studies show that microbiota can affect both occurence and treatment of depression because of secretes neurotransmitter and endocrine, inflammation and immune mechanism, brain derived neurotrophic factor (BDNF), hypothalamic pituitary adrenal (HPA) axis. Nutrition, on the other hand, is an issue that should be considered because of its effect on both the microbiota and depression. Therefore, the effects of nutrition and microbiota on depression have been discussed in the light of the evidence based data.